Carol Ann Susi’s agent said the actress died after a brief battle with cancer. Her age and other details on the circumstances of her death were not provided.
The veteran character actress has made numerous guest appearances on TV shows since the 1970s.
On the The Big Bang Theory, she was not seen on screen as the mother of Simon Helberg’s character Howard, but her character’s loud voice with a Brooklyn accent was instantly recognisable.
The executive producers of the CBS show said Susi was a beloved member of the The Big Bang Theory family, and they praised her “immense talent and comedic timing”.
Susi is survived by her brother Michael Susi and his wife Connie.