Suspected Class A and B controlled drugs, with an estimated street value of £150,000, were seized from a car in the Glengalliagh Road area yesterday afternoon.
Detectives from the Organised Crime Branch, investigating criminality linked to the INLA in Derry, made two arrests.
Among the items seized were quantities of suspected cocaine and amphetamines.
Two men, aged 37 and 38, have been charged with conspiracy to supply class A and B controlled drugs, possession of class A and B controlled drugs and possession of class A and B controlled drugs with intent to supply.
They are due to appear before Derry Magistrates court tomorrow.
Police are appealing to anyone who believes they have information regarding the sale and supply of drugs to come forward.